Hiroaki Yokoyama Selected Research

F(6) ATPase

4/2012	Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.
11/2010	Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice.
1/2010	Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to homocysteine.
3/2009	Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells: a role of acidosis-induced c-Src activation.

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Hiroaki Yokoyama Research Topics

Disease

11	Myocardial Infarction 01/2022 - 02/2009
10	ST Elevation Myocardial Infarction 01/2021 - 11/2013
5	Thrombosis (Thrombus) 11/2021 - 04/2014
4	Heart Failure 01/2021 - 11/2010
4	Rupture 01/2017 - 04/2014
3	AIDS-Related Complex (ARC) 01/2016 - 08/2015
3	Acidosis 04/2012 - 03/2009
2	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2022 - 01/2017
2	Cardiac Arrhythmias (Arrythmia) 08/2021 - 11/2014
2	Coronary Artery Disease (Coronary Atherosclerosis) 10/2020 - 06/2011
2	Ventricular Tachycardia 01/2019 - 01/2017
2	Acute Coronary Syndrome 02/2018 - 01/2015
2	Infarction (Infarctions) 04/2014 - 02/2009
2	Pathologic Constriction (Stenosis) 04/2014 - 02/2009
1	Weight Gain 01/2022
1	Insulin Resistance 01/2022
1	Obesity 01/2022
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022
1	Atrial Fibrillation 03/2021
1	Tachycardia (Tachyarrhythmias) 03/2021
1	Ventricular Remodeling 01/2021
1	Hemorrhage 10/2020
1	Immunoglobulin Light-chain Amyloidosis 08/2020
1	Amyloidosis 08/2020
1	Aortic Valve Stenosis (Aortic Stenosis) 06/2019
1	Ventricular Fibrillation 01/2019
1	Neointima 01/2018
1	Atherosclerotic Plaque (Atheroma) 01/2018
1	No-Reflow Phenomenon 01/2017
1	Stable Angina 01/2016
1	Appendicitis 01/2015
1	Angina Pectoris 04/2014
1	Cardiomegaly (Heart Hypertrophy) 04/2012
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 04/2012
1	Heart Valve Diseases (Valvular Heart Disease) 06/2011
1	Hypertension (High Blood Pressure) 11/2010
1	Penetrating Head Injuries (Penetrating Head Injury) 03/2010
1	Stroke (Strokes) 01/2010
1	Fistula 07/2009
1	Type 2 Diabetes Mellitus (MODY) 03/2009
1	Aneurysm (Aneurysms) 04/2004

Drug/Important Bio-Agent (IBA)

4	F(6) ATPaseIBA 04/2012 - 03/2009
3	LipidsIBA 01/2018 - 04/2014
3	MetalsIBA 04/2014 - 02/2009
2	CalciumIBA 01/2016 - 08/2015
2	Adenosine Triphosphate (ATP)IBA 11/2010 - 03/2009
1	Charcoal (Charbon)IBA 01/2022
1	Anti-Arrhythmia AgentsIBA 03/2021
1	Explosive Agents (Explosives)IBA 01/2021
1	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 08/2020
1	Amyloid (Amyloid Fibrils)IBA 08/2020
1	Prasugrel Hydrochloride FDA Link 12/2018
1	Clopidogrel (Plavix)FDA Link 12/2018
1	TroponinIBA 02/2018
1	Troponin IIBA 02/2018
1	Biomarkers (Surrogate Marker)IBA 01/2015
1	Class E Scavenger Receptors (Lectin Like Oxidized Low Density Lipoprotein Receptor 1)IBA 01/2015
1	omega-Chloroacetophenone (Mace)IBA 01/2015
1	Eicosapentaenoic AcidIBA 11/2014
1	Insulin-Like Growth Factor I (IGF-1)IBA 04/2012
1	Dihydrotachysterol (AT 10)IBA 06/2011
1	Pravastatin (Pravachol)FDA LinkGeneric 06/2011
1	Rosuvastatin Calcium (Crestor)FDA Link 06/2011
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2011
1	AdiponectinIBA 06/2011
1	LDL CholesterolIBA 06/2011
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2010
1	Adenosine (Adenocard)FDA LinkGeneric 11/2010
1	N 30IBA 01/2010
1	HomocysteineIBA 01/2010
1	VitaminsIBA 01/2010
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2010
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2010
1	PlatinumIBA 07/2009
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 03/2009
1	Telmisartan (Micardis)FDA Link 02/2009
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 02/2009
1	Enalapril FDA LinkGeneric 02/2009
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 02/2009

Therapy/Procedure

12	Percutaneous Coronary Intervention 01/2022 - 11/2013
4	Transcatheter Aortic Valve Replacement 11/2021 - 06/2019
4	Stents 01/2020 - 02/2009
2	Renal Dialysis (Hemodialysis) 03/2021 - 10/2020
2	Thrombectomy 10/2016 - 04/2014
2	Therapeutics 01/2015 - 04/2004
1	Heart Transplantation (Grafting, Heart) 08/2021
1	Radiofrequency Ablation 03/2021
1	Catheter Ablation 03/2021
1	Drug-Eluting Stents 10/2020
1	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2017
1	Bridge Therapy 01/2017
1	Defibrillators (Defibrillator) 01/2017
1	Catheters 04/2014
1	Glycemic Control 03/2009